Summary of rates* (no. per 100 subjects) by year for adverse reactions causing discontinuation
*Rates were calculated by weighting the annual rates by the number of subjects starting each year for each of the US Composite Study (3536 subjects) and the World Health Organization (1396 subjects) trials.
The following adverse reactions have also been observed: anemia, backache, dysmenorrhea, dyspareunia, complete or partial expulsion, prolonged menstrual flow, menstrual spotting, pain and cramping, and vaginitis.
The most serious adverse events associated with Paragard include:
- Ectopic pregnancy
- Intrauterine pregnancy
- Septic abortion
- Group A Streptococcal Sepsis (GAS)
- Pelvic inflammatory disease and endometritis
- Bleeding pattern alterations
The following adverse events have also been observed:
- Complete or partial expulsion
- Prolonged menstrual flow
- Menstrual spotting
- Pain and cramping